{"id":21426,"date":"2025-10-27T07:00:37","date_gmt":"2025-10-27T10:00:37","guid":{"rendered":"https:\/\/encodexa.com.br\/exames\/?p=21426"},"modified":"2025-10-13T20:13:21","modified_gmt":"2025-10-13T23:13:21","slug":"microbioma-vaginal-e-infeccoes-vaginais-de-dificil-tratamento-2","status":"publish","type":"post","link":"https:\/\/encodexa.com.br\/exames\/2025\/10\/27\/microbioma-vaginal-e-infeccoes-vaginais-de-dificil-tratamento-2\/","title":{"rendered":"Microbioma vaginal e infec\u00e7\u00f5es vaginais de dif\u00edcil tratamento"},"content":{"rendered":"\t\t
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Artigos<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Microbioma vaginal e infec\u00e7\u00f5es vaginais de dif\u00edcil tratamento.<\/p>\n

O microbioma vaginal refere-se \u00e0 comunidade de microrganismos (principalmente bact\u00e9rias) que vivem na vagina. Ele desempenha um papel crucial na manuten\u00e7\u00e3o da sa\u00fade vaginal, na prote\u00e7\u00e3o contra infec\u00e7\u00f5es e no apoio \u00e0 sa\u00fade reprodutiva.<\/p>\n

A microbiota vaginal deve ser dominada por esp\u00e9cies de Lactobacillus (por exemplo, L. crispatus, L. jensenii, L. iners), que produzem \u00e1cido l\u00e1tico, reduzindo o pH vaginal para < 4,5, inibem o crescimento de pat\u00f3genos pela produ\u00e7\u00e3o de pept\u00eddeos antimicrobianos e per\u00f3xido de hidrog\u00eanio, al\u00e9m de corroborar com a robustez da imunidade da mucosa.<\/p>\n

Quando o microbioma vaginal \u00e9 desestruturado, isto pode levar a um estado denominado disbiose e, em consequ\u00eancia, possibilitar v\u00e1rias infec\u00e7\u00f5es de dif\u00edcil tratamento, como a candid\u00edase vulvovaginal recorrente, vaginite aer\u00f3bica, tricomon\u00edase e, principalmente, infec\u00e7\u00f5es sexualmente transmiss\u00edveis (ISTs).<\/p>\n

A vaginose bacteriana \u00e9 um crescimento excessivo de anaer\u00f3bios (p. ex., Gardnerella vaginalis, Atopobium vaginae), decl\u00ednio de Lactobacillus e forma\u00e7\u00e3o de biofilme resistente a antibi\u00f3ticos, mostrando alta recorr\u00eancia (~50%) em 6 meses.<\/p>\n

A candid\u00edase vulvovaginal recorrente \u00e9 causada por crescimento excessivo de C\u00e2ndida albicans ou C. glabrata e, finalmente, a vaginite aer\u00f3bica causada por um desequil\u00edbrio com o crescimento de pat\u00f3genos aer\u00f3bicos (p. ex., E. coli, Streptococcus agalactiae) que requerem antibi\u00f3ticos e anti-inflamat\u00f3rios direcionados.<\/p>\n

Os desafios no tratamento do microbioma vaginal s\u00e3o baseados na resist\u00eancia a antibi\u00f3ticos e na quebra do biofilme. A forma\u00e7\u00e3o de biofilmes protege os microrganismos contra antibi\u00f3ticos e a\u00e7\u00e3o inflamat\u00f3ria local. Normalmente, na recomposi\u00e7\u00e3o do microbioma vaginal, \u00e9 necess\u00e1rio o uso de disruptores de biofilme, como \u00e1cido b\u00f3rico ou \u00e1cido l\u00e1urico.<\/p>\n

Encodexa<\/a>\u00a0e\u00a0Genoa<\/a>\u00a0s\u00e3o marcas LPCM.<\/p>\n

\u00a0<\/p>\n

Refer\u00eancias<\/p>\n

Ravel J. et al., PNAS, 2011 \u2013 Tipos de estados comunit\u00e1rios do microbioma vaginal
Ma B. et al., Nat Rev Microbiol, 2020 \u2013 Microbiota vaginal e sa\u00fade reprodutiva
Swidsinski A. et al., J Clin Microbiol, 2008 \u2013 Biofilme em BV<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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O microbioma vaginal refere-se \u00e0 comunidade de microrganismos (principalmente bact\u00e9rias) que vivem na vagina.<\/p>\n","protected":false},"author":2,"featured_media":21418,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[221],"tags":[],"post_folder":[],"class_list":["post-21426","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos"],"acf":[],"yoast_head":"\nMicrobioma vaginal e infec\u00e7\u00f5es vaginais de dif\u00edcil tratamento<\/title>\n<meta name=\"description\" content=\"O microbioma vaginal refere-se \u00e0 comunidade de microrganismos (principalmente bact\u00e9rias) que vivem na vagina. 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