{"id":21125,"date":"2025-09-15T19:44:47","date_gmt":"2025-09-15T22:44:47","guid":{"rendered":"https:\/\/encodexa.com.br\/exames\/?p=21125"},"modified":"2025-09-07T16:38:43","modified_gmt":"2025-09-07T19:38:43","slug":"a-historia-da-biopsia-liquida","status":"publish","type":"post","link":"https:\/\/encodexa.com.br\/exames\/2025\/09\/15\/a-historia-da-biopsia-liquida\/","title":{"rendered":"A hist\u00f3ria da Bi\u00f3psia L\u00edquida\u200b"},"content":{"rendered":"\t\t
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A hist\u00f3ria da bi\u00f3psia l\u00edquida.<\/p>

Em uma revis\u00e3o que explorou os desafios e oportunidades das CTCs (C\u00e9lulas Tumorais Circulantes) no c\u00e2ncer em 2010, o termo “bi\u00f3psia l\u00edquida” foi cunhado pela primeira vez por Catherine Alix-Panabi\u00e8res (foto) e Klaus Pantel. A Dra.\u00a0 Alix-Panabi\u00e8res \u00e9 pesquisadora do Hospital Universit\u00e1rio de Montpellier onde dirige o Laborat\u00f3rio de C\u00e9lulas Circulantes Raras Humanas e tamb\u00e9m \u00e9 professora na Universidade de Montpellier. Embora a bi\u00f3psia l\u00edquida tenha sido inicialmente usada apenas para definir CTCs, o termo foi rapidamente expandido para incluir outro biomarcador circulante \u2013 o DNA tumoral circulante (ctDNA).<\/p>

Apesar dessa inclus\u00e3o tardia, a presen\u00e7a de \u00e1cidos nucleicos livres de c\u00e9lulas na circula\u00e7\u00e3o sangu\u00ednea j\u00e1 havia sido descoberta muito antes. Pesquisas sobre muta\u00e7\u00f5es comuns em c\u00e2ncer, como as do gene RAS, tamb\u00e9m haviam sido exploradas usando ctDNA antes de sua ado\u00e7\u00e3o no campo da bi\u00f3psia l\u00edquida.<\/p>

Com as CTCs e o ctDNA consolidados como os dois componentes principais, a pesquisa no campo da bi\u00f3psia l\u00edquida expandiu-se rapidamente. As CTCs e o ctDNA t\u00eam sido destacados como biomarcadores progn\u00f3sticos na maioria dos tipos de tumores s\u00f3lidos, incluindo mama, pr\u00f3stata, pulm\u00e3o e colorretal.<\/p>

O c\u00e2ncer \u00e9 a segunda maior causa de morte no mundo e um grave problema de sa\u00fade p\u00fablica global. A detec\u00e7\u00e3o precoce e o tratamento adequado s\u00e3o cruciais para que pacientes com c\u00e2ncer melhorem seu progn\u00f3stico e suas chances de sobreviv\u00eancia. Atualmente, o padr\u00e3o-ouro para o diagn\u00f3stico de tumores ainda \u00e9 a bi\u00f3psia tecidual. Embora a bi\u00f3psia tecidual possa diagnosticar definitivamente tumores e seus subtipos, ela \u00e9 dif\u00edcil de coletar e, por ser um exame invasivo, \u00e9 propensa a causar danos aos pacientes e n\u00e3o \u00e9 conveniente para o monitoramento cont\u00ednuo da progress\u00e3o da doen\u00e7a. Como os tumores \u00e0s vezes s\u00e3o dif\u00edceis de detectar precocemente, \u00e9 complicado usar bi\u00f3psias teciduais para identific\u00e1-los com precis\u00e3o em um est\u00e1gio inicial da doen\u00e7a.<\/p>

A bi\u00f3psia l\u00edquida \u00e9 um m\u00e9todo minimamente invasivo de coleta de amostras que se concentra no sangue ou em secre\u00e7\u00f5es corporais para a detec\u00e7\u00e3o de altera\u00e7\u00f5es moleculares, c\u00e9lulas tumorais e metab\u00f3litos. Comparadas \u00e0s bi\u00f3psias teciduais, as bi\u00f3psias l\u00edquidas desempenham um papel no rastreamento precoce. Amostras comuns para bi\u00f3psia l\u00edquida s\u00e3o sangue e urina. Portanto, bi\u00f3psias l\u00edquidas s\u00e3o mais f\u00e1ceis de realizar do que bi\u00f3psias de tecido e s\u00e3o virtualmente n\u00e3o invasivas para o paciente, o que faz com que bi\u00f3psias l\u00edquidas tenham o potencial para monitoramento cont\u00ednuo da progress\u00e3o do tumor. V\u00e1rios marcadores moleculares podem ser detectados pela bi\u00f3psia l\u00edquida, como c\u00e9lulas tumorais circulantes (CTCs), DNA tumoral circulante (ctDNA), ves\u00edculas extracelulares derivadas de tumor (EVs), plaquetas educadas por tumor (TEPs – plaquetas que interagem com c\u00e9lulas tumorais e adquirem caracter\u00edsticas tumorais, podendo ser usadas como biomarcadores\u00a0) e RNA livre circulante (cfRNA). Atualmente, mais estudos se concentram na detec\u00e7\u00e3o de CTCs, ctDNA e exossomos.<\/p>

Encodexa<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Em uma revis\u00e3o que explorou os desafios e oportunidades das CTCs (C\u00e9lulas Tumorais Circulantes) no c\u00e2ncer em 2010<\/p>\n","protected":false},"author":2,"featured_media":21134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[221],"tags":[],"post_folder":[],"class_list":["post-21125","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos"],"acf":[],"yoast_head":"\nA hist\u00f3ria da Bi\u00f3psia L\u00edquida\u200b - Blog Encodexa .<\/title>\n<meta name=\"description\" content=\"Estudo canadense publicado na revista Nature, analisou o DNA de mais de 17.000 fam\u00edlias, visando elucida\u00e7\u00e3o da patogenia do autismo.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/encodexa.com.br\/exames\/2025\/09\/15\/a-historia-da-biopsia-liquida\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A hist\u00f3ria da Bi\u00f3psia L\u00edquida\u200b\" \/>\n<meta property=\"og:description\" content=\"Estudo canadense publicado na revista Nature, analisou o DNA de mais de 17.000 fam\u00edlias, visando elucida\u00e7\u00e3o da patogenia do autismo.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/encodexa.com.br\/exames\/2025\/09\/15\/a-historia-da-biopsia-liquida\/\" \/>\n<meta property=\"og:site_name\" content=\"Econdexa - 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