{"id":21122,"date":"2025-09-05T19:57:05","date_gmt":"2025-09-05T22:57:05","guid":{"rendered":"https:\/\/encodexa.com.br\/exames\/?p=21122"},"modified":"2025-09-07T16:39:16","modified_gmt":"2025-09-07T19:39:16","slug":"sindrome-de-li-fraumeni","status":"publish","type":"post","link":"https:\/\/encodexa.com.br\/exames\/2025\/09\/05\/sindrome-de-li-fraumeni\/","title":{"rendered":"S\u00edndrome de Li Fraumeni"},"content":{"rendered":"\t\t
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S\u00edndrome de Li Fraumeni.<\/p>

Tropeiro foi a designa\u00e7\u00e3o dada aos condutores de tropas de muares e cavalos entre as regi\u00f5es de produ\u00e7\u00e3o e os centros consumidores no Brasil a partir do s\u00e9culo XVIII. Eles transportavam g\u00eaneros para o com\u00e9rcio e animais para venda nas v\u00e1rias vilas e cidades pelas quais passavam. Tinham tamb\u00e9m uma certa import\u00e2ncia cultural de veicular ideias e not\u00edcias entre as comunidades numa \u00e9poca que n\u00e3o existiam estradas.<\/p>

Uma das principais vias de tropeiros era entre as regi\u00f5es sul e sudeste do Brasil desde Sorocaba em S\u00e3o Paulo passando por Lapa no Paran\u00e1 at\u00e9 Viam\u00e3o no Rio Grande do Sul.<\/p>

As tropas no Paran\u00e1 se deparavam com condi\u00e7\u00f5es privilegiadas e fartura dos campos de pastagens, permanecendo nestes locais per\u00edodos de at\u00e9 seis meses. Essas paradas estrat\u00e9gicas fizeram surgir pequenos n\u00facleos populacionais que se desenvolveram eventualmente em cidades.<\/p>

Alguns dos tropeiros deixaram diversas fam\u00edlias pelos caminhos e um deles foi fundador de uma muta\u00e7\u00e3o g\u00eanica que passou para seus descendentes nos diversos pontos onde criou la\u00e7os. O gene mutado \u00e9 o TP53 conhecido como guardi\u00e3o do genoma, um importante supressor de tumor, sendo sua altera\u00e7\u00e3o conhecida como s\u00edndrome Li Fraumeni. \u00a0<\/p>

Essa s\u00edndrome \u00e9 caracterizada clinicamente pelo risco aumentado em idade jovem de desenvolvimento de diversos tipos de c\u00e2ncer como c\u00e2ncer de mama, sarcomas de partes moles, osteossarcomas, leucemias, tumores do sistema nervoso central, suprarrenal, c\u00e2ncer de pulm\u00e3o e p\u00e2ncreas para mencionar alguns.<\/p>

A muta\u00e7\u00e3o no gene TP53 do tropeiro deu-se no DNA em s\u00edtio diferente dos descritos em outras regi\u00f5es do mundo fazendo a s\u00edndrome Li-Fraumeni no Brasil se apresentar com caracter\u00edsticas distintas. Uma delas est\u00e1 na probabilidade de desenvolver os tumores. Em geral homens e mulheres portadores de Li Fraumeni,\u00a0 t\u00eam cerca de 90 a 100% mais chances de terem c\u00e2ncer do que a popula\u00e7\u00e3o em geral. Mas no Brasil, mulheres t\u00eam cerca de 78% dessa probabilidade e em homens, ela \u00e9 menor do que 50%.<\/p>

No resto do mundo, muta\u00e7\u00f5es gen\u00e9ticas no TP53 tamb\u00e9m costumam causar c\u00e2ncer mais cedo – em 50% dos casos, antes dos 30 anos. No Brasil esse \u00edndice \u00e9 de 30%.<\/p>

Por isso, os brasileiros com a s\u00edndrome vivem mais tempo sem tumores e, por isso, t\u00eam maior probabilidade de terem filhos e portanto passar o gene adiante.<\/p>

Encodexa<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Tropeiro foi a designa\u00e7\u00e3o dada aos condutores de tropas de muares e cavalos entre as regi\u00f5es de produ\u00e7\u00e3o e os centros consumidores no Brasil a partir do s\u00e9culo XVIII.<\/p>\n","protected":false},"author":2,"featured_media":21145,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[221],"tags":[],"post_folder":[],"class_list":["post-21122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos"],"acf":[],"yoast_head":"\nS\u00edndrome de Li Fraumeni - Blog Encodexa .<\/title>\n<meta name=\"description\" content=\"Tropeiro foi a designa\u00e7\u00e3o dada aos condutores de tropas de muares e cavalos entre as regi\u00f5es de produ\u00e7\u00e3o e os centros consumidores no Brasil a partir do s\u00e9culo XVIII.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/encodexa.com.br\/exames\/2025\/09\/05\/sindrome-de-li-fraumeni\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"S\u00edndrome de Li Fraumeni\" \/>\n<meta property=\"og:description\" content=\"Tropeiro foi a designa\u00e7\u00e3o dada aos condutores de tropas de muares e cavalos entre as regi\u00f5es de produ\u00e7\u00e3o e os centros consumidores no Brasil a partir do s\u00e9culo XVIII.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/encodexa.com.br\/exames\/2025\/09\/05\/sindrome-de-li-fraumeni\/\" \/>\n<meta property=\"og:site_name\" content=\"Econdexa - 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