{"id":21055,"date":"2025-07-29T12:09:24","date_gmt":"2025-07-29T15:09:24","guid":{"rendered":"https:\/\/encodexa.com.br\/exames\/?p=21055"},"modified":"2025-07-27T16:06:19","modified_gmt":"2025-07-27T19:06:19","slug":"sindromes-hereditarias-de-cancer","status":"publish","type":"post","link":"https:\/\/encodexa.com.br\/exames\/2025\/07\/29\/sindromes-hereditarias-de-cancer\/","title":{"rendered":"S\u00edndromes heredit\u00e1rias de c\u00e2ncer"},"content":{"rendered":"\t\t
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S\u00edndromes heredit\u00e1rias de c\u00e2ncer.<\/p>

Entre 5 a 10% dos tumores est\u00e3o relacionados a s\u00edndromes heredit\u00e1rias de predisposi\u00e7\u00e3o ao c\u00e2ncer. Ou seja, um dos progenitores carrega uma muta\u00e7\u00e3o que \u00e9 transmitida a seus descendentes e tem como resultado a predisposi\u00e7\u00e3o ao desenvolvimento de tumores.<\/p>

Existem mais de 200 s\u00edndromes de susceptibilidade, por\u00e9m, apenas algumas tem alta penetr\u00e2ncia, o que significa que o indiv\u00edduo que possui a muta\u00e7\u00e3o tem alta probabilidade de desenvolver determinada neoplasia durante a vida.<\/p>

Fam\u00edlias que apresentam 2 ou mais indiv\u00edduos afetados pelo mesmo tipo de c\u00e2ncer ou tumores que ocorrem em gera\u00e7\u00f5es sucessivas, assim como indiv\u00edduos que desenvolvem mais de um tipo de c\u00e2ncer s\u00e3o algumas das caracter\u00edsticas dessas s\u00edndromes.<\/p>

A identifica\u00e7\u00e3o dessas fam\u00edlias \u00e9 muito importante pois possibilita o achado da muta\u00e7\u00e3o envolvida nesse processo permitindo a programa\u00e7\u00e3o de um rastreamento que resultar\u00e1 em diagn\u00f3stico e tratamento precoces, garantindo a sobreviv\u00eancia dos portadores das altera\u00e7\u00f5es moleculares.<\/p>

Algumas dessas s\u00edndromes s\u00e3o mais comuns como por exemplo as muta\u00e7\u00f5es em BRCA1 e 2, que predisp\u00f5e ao desenvolvimento do c\u00e2ncer de mama e ov\u00e1rio, pr\u00f3stata e c\u00e2ncer de mama em homens. A s\u00edndrome de Lynch tamb\u00e9m \u00e9 mais prevalente e se caracteriza pelo desenvolvimento do c\u00e2ncer de c\u00f3lon e reto e endom\u00e9trio nas mulheres.<\/p>

Uma s\u00edndrome relativamente comum no Brasil \u00e9 a s\u00edndrome de Li-Fraumeni que est\u00e1 relacionada ao desenvolvimento de m\u00faltiplos tumores como os sarcomas \u00f3sseos e de partes moles, tumores do sistema nervoso central, melanoma, c\u00e2ncer de mama, p\u00e2ncreas e da gl\u00e2ndula suprarrenal.<\/p>

Fique atento a sua hist\u00f3ria familiar de c\u00e2ncer. Se voc\u00ea fizer parte de uma fam\u00edlia com essas caracter\u00edsticas, procure um m\u00e9dico e descreva sua hist\u00f3ria. Isso permitir\u00e1 que voc\u00ea e seus descendentes sejam acompanhados e tratados precocemente e vivam com plenitude.<\/p>

Encodexa.<\/a><\/p>

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Entre 5 a 10% dos tumores est\u00e3o relacionados a s\u00edndromes heredit\u00e1rias de predisposi\u00e7\u00e3o ao c\u00e2ncer. <\/p>\n","protected":false},"author":2,"featured_media":21070,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[221],"tags":[],"post_folder":[],"class_list":["post-21055","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos"],"acf":[],"yoast_head":"\nS\u00edndromes heredit\u00e1rias de c\u00e2ncer - Blog Encodexa .<\/title>\n<meta name=\"description\" content=\"Entre 5 a 10% dos tumores est\u00e3o relacionados a s\u00edndromes heredit\u00e1rias de predisposi\u00e7\u00e3o ao c\u00e2ncer. 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