{"id":21023,"date":"2025-08-18T11:59:32","date_gmt":"2025-08-18T14:59:32","guid":{"rendered":"https:\/\/encodexa.com.br\/exames\/?p=21023"},"modified":"2025-07-11T15:22:40","modified_gmt":"2025-07-11T18:22:40","slug":"genes-de-predisposicao-ao-cancer-de-prostata-hereditario-2","status":"publish","type":"post","link":"https:\/\/encodexa.com.br\/exames\/2025\/08\/18\/genes-de-predisposicao-ao-cancer-de-prostata-hereditario-2\/","title":{"rendered":"Genes de Predisposi\u00e7\u00e3o ao C\u00e2ncer de Pr\u00f3stata Heredit\u00e1rio"},"content":{"rendered":"\t\t
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Genes de predisposi\u00e7\u00e3o ao c\u00e2ncer de pr\u00f3stata heredit\u00e1rio.<\/p>

At\u00e9 10% dos casos de c\u00e2ncer de pr\u00f3stata devem-se a heran\u00e7a gen\u00e9tica. Um irm\u00e3o ou pai com c\u00e2ncer de pr\u00f3stata mais que dobra o risco de desenvolvimento da doen\u00e7a. Quando mais de um membro familiar \u00e9 afetado, principalmente em faixas et\u00e1rias mais jovens, esse risco \u00e9 ainda maior.<\/p>

Existe um grupo de genes que se tem demonstrado muito relevante na identifica\u00e7\u00e3o desses casos e sua heran\u00e7a n\u00e3o s\u00f3 \u00e9 importante para o aconselhamento gen\u00e9tico, mas influencia a estrat\u00e9gia de rastreamento e mais importante, do tratamento, principalmente durante a progress\u00e3o da doen\u00e7a ap\u00f3s o tratamento prim\u00e1rio.<\/p>

As muta\u00e7\u00f5es de BRCA1 e BRCA2 est\u00e3o relacionadas ao desenvolvimento do c\u00e2ncer de pr\u00f3stata e as fam\u00edlias ter\u00e3o hist\u00f3ria de c\u00e2ncer de ov\u00e1rio e mama nas mulheres. Outros genes tamb\u00e9m s\u00e3o importantes e predisp\u00f5em a outros tipos de tumores como a muta\u00e7\u00e3o de TP53 na s\u00edndrome de Li Fraumeni que est\u00e1 relacionada ao desenvolvimento de sarcomas \u00f3sseos e de parte moles, tumores do SNC, melanoma, pulm\u00e3o, mama etc.<\/p>

Com o conhecimento da hist\u00f3ria familiar de c\u00e2ncer de seu paciente voc\u00ea pode tra\u00e7ar uma estrat\u00e9gia de rastreamento do c\u00e2ncer de pr\u00f3stata e de outros tumores, permitindo um tratamento precoce, aumentando seu potencial curativo.<\/p>

Sabemos que os n\u00edveis de PSA podem ser menores nesses indiv\u00edduos e que eventualmente a busca do c\u00e2ncer de pr\u00f3stata deve ser feita pela resson\u00e2ncia magn\u00e9tica e a bi\u00f3psia, eventualmente ser indicada mais precocemente.<\/p>

O mais importante \u00e9 a indica\u00e7\u00e3o da terapia na progress\u00e3o da doen\u00e7a. A presen\u00e7a dessas muta\u00e7\u00f5es sugere a indica\u00e7\u00e3o de quimioterapia na doen\u00e7a avan\u00e7ada ou o uso dos novos inibidores da PARP.<\/p>

Encodexa<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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At\u00e9 10% dos casos de c\u00e2ncer de pr\u00f3stata devem-se a heran\u00e7a gen\u00e9tica. Um irm\u00e3o ou pai com c\u00e2ncer de pr\u00f3stata mais que dobra o risco de desenvolvimento da doen\u00e7a.<\/p>\n","protected":false},"author":2,"featured_media":20977,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[221],"tags":[],"post_folder":[],"class_list":["post-21023","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigos"],"acf":[],"yoast_head":"\nGenes de Predisposi\u00e7\u00e3o ao C\u00e2ncer de Pr\u00f3stata Heredit\u00e1rio - Blog Encodexa .<\/title>\n<meta name=\"description\" content=\"At\u00e9 10% dos casos de c\u00e2ncer de pr\u00f3stata devem-se a heran\u00e7a gen\u00e9tica. 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